St. Joseph's Hospital in Parkersburg, established in the early 1900s, quickly became a vital part of the growing city. Starting with 21 beds in 1902, the hospital expanded over the years, adding a School of Nursing in 1905, which graduated its first nurse in 1908. The nursing school flourished, forming an Alumnae Association in 1910. During World War I, five nurses from St. Joseph’s served, returning to take on leadership roles at the hospital.

The hospital's demand grew rapidly, leading to further expansions, including a second annex in 1924 and a new location at 19th Street and Murdoch Avenue in 1931, largely funded by the community. During World War II, 33 nursing graduates served in the Armed Forces, and the hospital trained cadet nurses under government programs. Further growth continued in the 1950s and 1960s, with the addition of the C.Z. Ruth Annex, increasing bed capacity by 100.

Sister Rita Marie Von Berg led the hospital through significant developments in the 1960s and 1970s, including a new physician’s office building and a parking garage. The last nursing class graduated in 1969, with the School of Nursing building later repurposed for other hospital services. Over its history, St. Joseph's School of Nursing graduated 803 women, many of whom continued to serve the hospital and community.

When the School of Nursing closed in 1969, the future of its legacy was uncertain. However, more than thirty years later, a partnership formed to create a permanent scholarship fund, ensuring that the memory of the school and its alumnae would live on. Initiated by the Nursing Alumnae Association, with support from the Sisters of Saint Joseph of Wheeling and St. Joseph's Hospital, the scholarship honors the school’s legacy by continuing to support the education of nursing professionals.

Sr. Marguerite O'Brien, President of the Sisters of Saint Joseph of Wheeling at the time, expressed gratitude for being part of the effort to uphold the compassionate care that was a hallmark of St. Joseph's. Alumnae Association President Sue Smittle emphasized that the scholarship serves as a perpetual memorial, preserving the memory of those who inspired the students during their time at the School of Nursing. Peggy Heater, Director of Nursing, noted that the scholarship reflects the hospital's commitment to continuing the ethic of care in the community. The 2005 centennial of the School of Nursing marked a significant milestone in celebrating its enduring impact.