Holly Christine Jackson-Wuller was born in Parkersburg to Harold "Bub" and Sherry Barton Jackson. She graduated from Parkersburg South High School in 1996, where she was active in basketball, cheerleading and was a member of South's first crew team. She attended Queens College, then Marshall University, where she was a member of the dance team. She attended North Parkersburg Baptist Church. She was married to Sean T. Wuller.
Holly passed away on May 14, 2003, after a battle with cancer at the age of 24. A memorial scholarship was established with the Parkersburg Area Community Foundation to honor Holly's memory and to be able to help students pursue higher educational goals.